Diabetes
Conditions
Sponsors
Weishan People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. No SGLT-2i drugs have been used in the past; 2. HbA1C is less than 9% and fasting blood glucose is less than 10mmol/ L; 3. Aged 30 to 65, weight >=50kg; 4. No previous history of gout or hyperuricemia, and no uric acid-lowering medication has been used.
Exclusion criteria
Exclusion criteria: 1. Any chronic diseases such as hypertension, coronary heart disease, etc.; 2. Previous hyperuricemia is under medical treatment; 3. Gastrointestinal, liver, kidney, respiratory, cardiovascular, metabolic, immune or hormonal disorders; 4. Have had gastrointestinal surgery (except appendectomy); 5. Central nervous system disease (such as epilepsy) or mental disorders or neurological disorders; 6. Associated postural hypotension, history of dizziness or vertigo; 7. Chronic or associated acute infections; 8. History of related allergies/hypersensitivity reactions (including 1. Allergies to drugs or their excipients); 9. Long half-life drug 10 was taken for at least one month before study administration or during the trial or for less than; 10. half-lives of the corresponding drug. Participated in trials of other study drugs within 2 months prior to study administration or during the trial; 11. Drug abuse; 12. Blood donation (more than 100 mL within 4 weeks prior to study administration or during the trial); 13. Excessive physical activity (within 1 week prior to study administration or during study period); 14. Failure to follow the center's dietary regimen; 15. Baseline QT/QTc intervals were significantly longer (for example, QTc intervals were repeatedly greater than 450 ms); 16. A history of urinary and reproductive diseases and acute urinary tract infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| uric acid; | — |
Countries
China
Contacts
Public ContactLi Xiaoe
Weishan People's Hospital
Outcome results
None listed