cardiovascular diseases
Conditions
Interventions
Experiment group:standard on-pump cardiac surgery+oral colchicine
Control group:standard on-pump cardiac surgery+oral placebo
Sponsors
Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients undergoing on-pump cardiovascular surgery; 2. Aged 50-75 (including 50 and 75), male or female; 3. Have signed the Informed Consent Form (ICF); 4. Patients have New York Heart Association Class I-II.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing emergency surgery; 2. Patients undergoing deep hypothermic circulatory arrest (DHCA) surgery; 3. Patients with atrial fibrillation who need radiofrequency catheter ablation (RFCA); 4. Patients with coronary artery disease (CAD) who need percutaneous transluminal coronary intervention (PCI) or CABG; 5. Poor hepatorenal dysfunction (Child Pugh Class B or C, eGFR 10 pg/ml, PCT > 0.5 ng/ml, CRP > 10 mg/L); 7. Predicitive mortality of European System for Cardiac Operative Risk Evaluation (EuroScore II) > 3% 8. Patients who had received cardiac surgery; 9. Patients who are diagnosed with inflammatory immune diseases; 10. Patients who received treatment of colchicine or hormone previously; 11. Patients who had history of tumor or infectious disease; 12. Patients who had colchicine allergy or intolerance; 13. Patients who receive more than 120 min of aortic cross clamp (ACC); 14. Patients who need ventricular outflow reconstruction in the surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponin T; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination;Erythrocyte sedimentation rate;PCT;Myocardial enzyme profile;Biochemical complete inspection;CRP;Troponin I; | — |
Countries
China
Contacts
Public ContactWang Dongjin
Nanjing Drum Tower Hospital, The affiliated Hospital of Nanjing University Medical School
Outcome results
None listed