esophageal stricture after circumferential endoscopic submucosal dissection of early esophageal cancer
Conditions
Interventions
Experimental group:Autologous esophageal mucosal transplantation
The control group:Titanium clamp
Sponsors
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, LinHai, Zhejiang, China
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with EEC expected to result in a above 3/4-circumference or longitudinal axis length between 3-6cm post-ESD artificial ulcer; 2. Patients who can tolerate endoscopic treatment under general anesthesia; 3. Patients who agreed to participate in the clinical trial and signed informed consent for surgery.
Exclusion criteria
Exclusion criteria: 1. Patients with eating disorders and absorption disorders caused by other reasons; 2. Patients with diabetes, autoimmune diseases, and a recent history of taking drugs such as hormones and immunosuppressant; 3. Patients with severe cardiovascular and cerebrovascular diseases, severe hepatic and renal insufficiency, and a history of severe chronic pulmonary disease; 4. Patients with acute or chronic infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| with or without stricture occurrence;adverse events;Mucosal survival rate;Stooler grade and SF-36 score of quality of Life Evaluation Scale;Wound healing;Serum related inflammatory cytokine concentration, Masson staining results, RT-PCR and WB detection of related molecule expression; | — |
Countries
China
Contacts
Public ContactXingli Mao
Taizhou Hospital of Zhejiang Province
Outcome results
None listed