Effect of Ringer's solution bicarbonate on lactic acid during liver transplantation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000040114

Enrollment

Unknown

Registered

2020-11-21

Start date

2020-11-30

Completion date

Unknown

Last updated

2021-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver transplantation

Interventions

Experimental group:Sodium bicarbonate Ringer's solution was used

Control group:Sodium lactate solution was used

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) 18-70 years old; (2) ASA I-III; (3) Liver transplantation is planned; (4) Be willing to sign informed consent

Exclusion criteria

Exclusion criteria: (1) Hyperlactic acidemia, LA>2mmol/L; (2) Renal insufficiency (CKD> stage 2); (3) Hypohepatia (Child C ), acute severe hepatitis, hepatic coma and hepatic encephalopathy stage 3; (4) Hepatorenal syndrome and hepatopulmonary syndrome; (5) Cardiac insufficiency, NYHA III-IV; (6) Existing circulatory dysfunction should be maintained with vasoactive drugs; (7) Diabetic nephropathy, or diabetes (taking metformin treatment).

Design outcomes

Primary

Measure	Time frame
lactic acid;pH;BE;	—

Secondary

Measure	Time frame
Blood Pressure;cardiac output;cardiac index;CVP;	—

Countries

China

Contacts

Public ContactLiu Cunming

Jiangsu Province Hospital

1335587409@qq.com+86 13951890866

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026