chronic gastritis with Helicobacter pylori infection
Conditions
Interventions
Group A:Weibimei with triple therapy 14 days
Group B:Weibimei quadruple therapy 10 days +Weibimei 18 days
Control Group C:CBS with triple regimen 14 days
Sponsors
Peking University First Hospital/Beijing Friendship Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age from 18 to 65 years old; 2. Patients with HP-positive chronic gastritis (all selected subject must be diagnosed through endoscopy. The results should be obtained within 3 months prior to trial); 3. Liver, kidney, and heart functions are normal within 3 months (Urine routine, blood biochemistry, electrocardiogram, etc. are all normal); 4. Patients with positive urea breath test within 1 month before and after gastroscopy; 5. The result of penicillin skin test is negative (the test could no been needed only if the patient had takedn oral penicillin before without side effects); 6. Only patients who have not received formal HP eradication treatment before(initial treatment)could be involved; 7. Those who agree to participate in this trial and sign the informed consent form; 8. patients who agree to participate in the whole course of trials.
Exclusion criteria
Exclusion criteria: 1. Those who have used antibiotics, bismuth or PPI within 4 weeks before treatment; 2. Pregnant or lactating women; 3. Patients with other serious diseases that would affect the evaluation of this study, such as severe liver disease, heart disease, kidney disease, malignant tumor or alcoholism; 4. Those who are allergic to the drugs used in this study or their components; 5. those who had Participated in other drug research within 3 months before using the research drug; 6. the patients suffered not only gastritis, but also gastric ulcer and/or duodenal ulcer, or reflux esophagitis, and other situations in which PPI or bismuth must be continued after the eradication of Helicobacter pylori; 7. Patients who cannot express their main complaints correctly, such as mental illness, severe neurosis, or cannot cooperate with the trial; 8. There is other situations that The investigator believes that it is inappropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the rate of H. pylori infection; | — |
Countries
China
Contacts
Public ContactFulian Hu/Shutian Zhang
Peking University First Hospital
Outcome results
None listed