Postoperative pain
Conditions
Interventions
Esketamine group:The esketamine group received an intravenous esketamine bolus (0.1 mg/kg) after induction of anesthesia, followed by a continuous infusion of 0.1 mg/kg/h until the completion of surge
Control group:In the control group, patients received volume-matched saline as both a bolus after induction of anesthesia and a continuous intraoperative infusion. Postoperatively, patient-controlled
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. ASA I~III level; 3. Scheduled for elective video-assisted thoracoscopic lung resection under general anesthesia ; 4. Plan to be hospitalized >= 48 hours after surgery.
Exclusion criteria
Exclusion criteria: 1. Known allergy to study medications; 2. Contraindications to nonsteroidal anti-inflammatory drugs (NSAIDs); 3. Psychiatric disorders; 4. History of chronic pain; 5. Communication difficulties; 6. Emergency or trauma cases; 7. History of intraoperative awareness; 8. Planned postoperative transfer to intensive care unit (ICU); 9. Unwilling to use patient controlled intravenous analgesia (PCIA).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score at rest;VAS pain score on coughing;The requirement for supplemental analgesics;Time to recovery of bowel function;hypoxemia;hypotension;nausea and vomiting;itching;dreaminess;nightmare;illusion;delirium;restlessness;orientation difficulty;laryngospasm;blurred vision;tachycardia;salivation; | — |
Countries
China
Contacts
Public ContactJi Fuhai
The First Affiliated Hospital of Soochow University
Outcome results
None listed