Sepsis shock
Conditions
Interventions
HP combine CVVHDF group:HP combine CVVHDF group
Sponsors
The 940 Hospital of PLA Joint Service Support Force
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients older than 18 and younger than 85 years old; 2. Patients with septic shock: according to the definition of sepsis 3.0, patients with sepsis who have no response to fluid resuscitation need to use vasoactive drugs to maintain the mean arterial pressure above 65mmhg; 3. Patients who have received standard treatment including fluid resuscitation, vasoactive drugs, antibiotics, respiratory support, nutritional support and vital signs monitoring according to SSCM guidelines 2016; 4. The patients who signed the informed consent form (those without the ability to sign will be signed by the client).
Exclusion criteria
Exclusion criteria: 1. Patients with hypersensitivity to hemoperfusion and filter materials; 2. Patients who received vasoactive drugs and fluid resuscitation and whose mean arterial blood pressure could not be maintained above 65mmhg; 3. Pregnant or lactating women; 4. Patients with drug abuse, serious mental illness, history of alcohol abuse and can not be terminated; 5. Patients with congenital immunodeficiency disease, HIV infection and depletion of CD4 + lymphocytes; 6. Patients who have received organ transplantation within one year; 7. Patients who have been admitted to ICU in recent 28 days; 8. Patients with end-stage renal disease requiring maintenance dialysis; 9. Patients with acute myocardial infarction or congestive heart failure (ejection fraction less than 35%, NYHA grade IV) in the past 4 weeks; 10. Patients with severe leukopenia (< 0.5 x 10^9 / L) or severe thrombocytopenia (< 30 x 10^9 / L); 11. Patients with malignant tumors that cannot be removed (such as surgical patients who cannot be treated surgically) or whose weight is less than 35 kg; 12. Patients with uncontrollable bleeding (acute massive bleeding within 24 hours, more than 3 UPC within 24 hours); 13. Patients with severe trauma within 36 hours; 14. Patients with acute pulmonary embolism; 15. Patients with transfusion reaction; 16. Patients with III degree burn, less than 7 days; 17. Other situations that the researchers considered could not be included in the study, such as the terminal state of chronic diseases, no survival or discharge possibility; 18. Subjects who have participated in or participated in another interventional clinical study within 30 days before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortability at 28 days after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score;APACHE II score;Vital signs;liver, kidney function and electrolyte;IL-6;PCT;TNF-a;CRP;Blood routine;Hemodynamic monitoring;lactic acid;duration of mechanical ventilation;duration in ICU; | — |
Countries
China
Contacts
Public ContactDong Liu
The 940th Hospital of PLA Joint Service Support Force
Outcome results
None listed