Lung Cancer
Conditions
Interventions
experimental group:Neoadjuvant targeting
control group:Standard AP scheme
Sponsors
Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with stage III a4-n2, III a-t4-n0 NSCLC who were consistent with AJCC eighth edition TNM staging and Robinson classification (see research background) by imaging and pathological examination, and egfrm + was detected by pathological tissue (arms method) or peripheral blood gene detection (NGS); 2. Patients with clear tumor boundary and measurable volume (measurable lesions); 3. Patients without history of lung tumor surgery; 4. Patients without previous chemoradiotherapy history; 5. Patients with KPS score >= 80; 6. Patients whose expected survival time is more than 180 days; 7. Those who sign the informed consent form will join voluntarily.
Exclusion criteria
Exclusion criteria: 1. Patients with serious uncontrolled basic medical diseases; 2. Patients with other malignant tumors; 3. Patients with liver and kidney dysfunction; 4. Patients with surgical contraindications; 5. Patients with superior sulcus type non-small cell lung cancer; 6. Patients younger than 18 years old or older than 80 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical resection rate, PCR rate, MPR rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| QOL;overall survival;progression-free survival; | — |
Countries
China
Contacts
Public ContactXie Ke
Sichuan Provincial People's Hospital
Outcome results
None listed