COPD
Conditions
Interventions
control group:regular treatment + placebo
treatment group:regular treatment + fudosteine
Sponsors
Zhongshan Hospital Affiliated Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients over 18 years old who were diagnosed with COPD at a stable stage according to the 2011 edition of Guidelines for diagnosis and Treatment of Chronic Obstructive Pulmonary Disease formulated by the Ministry of Health; (2) Pulmonary function grades of COPD patients were diagnosed as grade 2 and grade 3 according to the 2011 GOLD Guidelines; (3) Informed consent of prospective researchers, with good cooperation and compliance, without reading, writing or communication barriers; (4) The patient has been living around the city for a long time, which is convenient for the medical unit to follow up the patient and prevent the patients from falling off; (5) Previous studies judged it as neutrophil type COPD (the proportion of neutrophils in induced sputum was greater than 60% and the proportion of eosinophils was less than 3%).
Exclusion criteria
Exclusion criteria: (1) Combined with untreated pneumothorax, tympanic membrane rupture or other middle ear lesions, pulmonary hypertension, active hemoptysis and other diseases; (2) Recent oral or facial or skull surgery or injury; (3) Intracranial pressure higher than 20mmHg; (4) Complicated with systemic infection or autoimmune disease; (5) Simple asthma complicated with giant pulmonary bullae, diffuse bronchiolitis or serious lesions of heart, liver, kidney and other important organs; (6) The disease was unstable and AE appeared frequently in the first 3 months before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine examination;pulmonary function;IgE in blood;chest CT;Questionnaire score;induced sputum;medical history; | — |
Countries
China
Contacts
Public ContactChen Zhihong
Zhongshan Hospital Affiliated Fudan University
Outcome results
None listed