thin endometrial infertility
Conditions
Interventions
Stem cells combined with collagen scaffolds transplantation group:Stem cells combined with collagen scaffolds transplantation
collagen scaffold transplant group:collagen scaffold transplant
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) 20 to 39 years of age,primary or secondary infertility undergoing in vitro fertilization embryo transfer, >=4 high-quality frozen embryos (defined as 7-9c/II 0 or blastocysts of 4BC and above) and of which >= 2 grade I embryos or blastocysts of 4BC and above; (2) Diagnosed as grade III or higher (according to the 1997 European Gynecological Endoscopy Associations uterine adhesion classification standard) or score > 8 points (according to the 1988 American Reproductive Association uterine adhesion standard) by hysteroscopy, and intrauterine adhesiolysis have been performed, re-examination of hysteroscopy showed normal uterine cavity morphology, and with a score of 4mg/day, the maximum dose is 8mg/day and above), and the endometrial thickness after treatment is less than 7mm; (4) 18kg/m2< BMI < 24 kg/m2; (5) Cov-19 nucleic acid test negative; (6) Those who voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Those who have not been cured of sexually transmitted diseases. (2) those who participate in other clinical researchers in the past three months. (3) those who were positive in serum pregnancy test. (4) patients with coagulation dysfunction or other blood system diseases. (5) patients with severe heart disease, unstable angina pectoris, cardiac insufficiency above III grade, acute myocardial infarction and / or old myocardial infarction, diagnosed as hypertension according to the 2010 Chinese guidelines for the prevention and treatment of hypertension. (6) patients with active genital tuberculosis. (7) patients with immune system diseases. (8) any disease that affect pregnancy outcome: untreated hydrosalpinx, untreated uterine polyps, untreated uterine infection, III~ IV stage endometriosis, adenomyosis, ovarian cyst > 4cm, uterine myoma diameter > 2cm, multiple myoma, intramural and submucosal myoma, poor healing of cesarean incision, pelvic and abdominal benign tumor > 4cm, pituitary tumors and malignant tumors. (9) abnormal uterine bleeding. (10) patients with severe liver and renal function damage, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were 2.5 times higher than the normal upper limit, serum creatinine (Cr) and urea nitrogen (BUN) were 2 times higher than the normal upper limit. (11) patients who were not suitable to be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endometrial thickness;clinical pregnancy;biochemical pregnancy;livebirth;endometrial pattern;?Np63;Ki67;estrogen receptor alpha;von Willebrand factor;Menstrual changes; | — |
Countries
China
Contacts
Public ContactLi Yanping
Xiangya Hospital, Central South University
Outcome results
None listed