Induction of general anesthesia
Conditions
Interventions
Optimal drug concentration group:Different concentrations of remazolam toluenesulfonic acid were applied to explore the drug concentration needed to achieve the depth of anesthesia.
Remazolam toluenesulfonic acid group:The best drug concentration of toluene sulfonic acid was applied during induction of general anesthesia, and the peak time of drug effect was observed
The propofol group:Propofol 2.5mg/kg was routinely induced by general anesthesia
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60, regardless of gender; 2. 19kg/m2 <= BMI <= 30kg/m2; 3. ASAI-II;General anesthesia within 2 hours(Endotracheal intubation is to be performed); 4. Clearly understand and voluntarily participate in the study, and the informed consent shall be signed by himself or his legal guardian.
Exclusion criteria
Exclusion criteria: 1. Known allergy or contraindication to benzodiazepines, flumazine, anesthetics; 2. Patients with a history of severe liver and kidney dysfunction, myasthenia gravis, and other abnormal laboratory tests and tests were considered clinically significant; 3. Those who have taken benzodiazepines for a long time and have used sedation or opioid analgesics in the past 5 days; 4. A pregnant or lactating woman; 5. Mallampati Score is assessed as 4 points; 6. The investigator considers the subjects to have any factors that would make them unfit to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Entropy index;Drug effect peak time T; | — |
Countries
China
Contacts
Public ContactWenyuan Wang
Zhejiang Provincial People's Hospital
Outcome results
None listed