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The effect and mechanism of platelet activation on leukocytes function in periodontal immune inflammation

The effect and mechanism of platelet activation on leukocytes function in periodontal immune inflammation

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000039875
Enrollment
Unknown
Registered
2020-11-13
Start date
2020-11-10
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal diseases

Interventions

Periodontitis group:non surgical periodontal treatment
periodontitis with AS:non surgical periodontal treatment

Sponsors

Peking University School and Hospital of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The inclusion of periodontitis 1) age between 18 to 60 years old; 2) systemic healthy and presented at least 20 functional teeth in the mouth; 3) at least 8 teeth with probing depth (PD) > 5mm and clinical attachment loss (AL) > 3mm, with radiographic evidence of alveolar bone loss, and at least 3 of them were not incisors or first molars; 4) no periodontal treatment in the previous 6 months; 5) no antibiotics in the precious 3 months. The inclusions of Patients with periodontitis and atherosclerosis are the similar to the above criteria except that the patient had both periodontitis and atherosclerosis.

Exclusion criteria

Exclusion criteria: 1) Pregnancy or lactation; 3) other systemic diseases; 4) dysfunction of blood coagulation; 5) smoker; 6) denied to join the study or sign the consent form.

Design outcomes

Primary

MeasureTime frame
periodontal probing depth;attachment loss;bleeding index;Blood cell analysis;serum biochemical indexes;membrane receptors of platelets and leukocytes;inflammatory factors;

Countries

China

Contacts

Public ContactRuifang Lu

Peking University School and Hospital of Stomatology

kqrflu@bjmu.edu.cn+86 10-82195368

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026