delirium after cerebrovascular intervention
Conditions
Interventions
treatment group:Dexmedetomidine hydrochloride injection (1ml:100ug
1ug/kg loading dose) was added to 100mL saline solution for 10min, and then injected with a micropump at 0.5ug/kg/h.
control group:0.9% sodium chloride injection, the same dose of normal saline
Sponsors
Department of Anesthesiology, Shandong provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) After the patients have a full understanding of the purpose and significance of this trial, they voluntarily participate in this trial and sign the informed consent. 2) Type of operation: cerebral vascular stent implantation under general anesthesia, preoperative cerebral angiography showed > 70% stenosis, or = 30ml/min; e. Hemoglobin: >= 90g/L; f. Platelet count: >= 75.0 x 10^9g/L; g. Neutrophil count: >= 1.5 x 10^9g/L; 6) No mental disorder, normal consciousness and normal communication; 7) ASA grade I-II; 8) No contraindications to the use of dexmedetomidine.
Exclusion criteria
Exclusion criteria: 1) Preoperative history of cerebral ischemia with left sensory and motor abnormalities in one or both limbs; 2) Patients with possible adverse reactions to dexmedetomidine use, including bradycardia (heart rate = 160mmHg, and/or diastolic blood pressure >= 100mmHg), or hypotensive patients (systolic blood pressure upper limit of 2.5 times normal value of ALT and/or AST, > 1.5 times normal value of total bilirubin, and > 1.5 times normal value of serum creatinine); 12) Randomly assigned to use alpha 2 adrenergic agonists or antagonists during the first 14 days; 13) Patients who had used benzodiazepines, barbiturates and other sedatives in the previous 7 days (those whose elution period exceeded 5 half-lives could be included); 14) Persons with a history of drug abuse, drug abuse and alcohol abuse, in which alcohol abuse was defined as drinking more than 2 units of alcohol per day on average (1 unit =360ml beer or 45ml alcohol: 40% white wine or 150ml wine); 15) Allergic to dexmedetomidine, midazolam, fentanyl and other drug ingredients or components; 16) The investigator considers that there are any other conditions that are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the proportion of patients with delirium within 7 days of medication.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety evaluation was required before and after administration. If AE appeared during the test, it was necessary to follow up to the end of AE, stabilize, return to the baseline level or lose follow-up.; | — |
Countries
China
Contacts
Public ContactMing Hou
Department of Anesthesiology, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University
Outcome results
None listed