The efficacy and safety of micro-dose intrathecal morphine application in Percutanous Endoscopic Lumbar Discectomy: a randomized controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000039842

Enrollment

Unknown

Registered

2020-11-12

Start date

2020-11-02

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lumbar disc herniation

Interventions

experimental group:Micro-dose intrathecal morphine

control group:normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Over 18 years old; 2. Under indication of single segment percutaneous endoscopic lumbar discectomy; 3. ASA score more than level 3.

Exclusion criteria

Exclusion criteria: 1. Morphine use history within 3 days; 2. Refusal to participate in this study; 3. Contraindications of morphine use, lumbar puncture; 4. Elderly patients (over 65 years old); 5. OSAS,COPD; 6. Obese patients (BMI >= 30); 7. Mental disorders, drug addicts; 8. Cognitive impairment, unable to cooperate with pain assessment; illiteracy, deaf/mute; 9. Chronic cough; 10. Pregnant and lactating women; 11. Vulnerable subjects, such as those without informed consent, without family members and vagrants, as well as soldiers and prisoners.

Design outcomes

Primary

Measure	Time frame
Peri-operative VAS score;	—

Secondary

Measure	Time frame
The use of analgesia peri-operatively;Side effects of ITM;Vital signs intraoperatively;Functional evaluation;Radiographical evaluation;Anesthetic satisfaction;	—

Countries

China

Contacts

Public ContactSun Haolin

Peking University First Hospital

sunhaolin@vip.163.com+86 13681146156

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 11, 2026