Suspected positive infection
Conditions
Interventions
single arm:No intervention
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Subjects who meet all the following selection criteria and do not meet any of the exclusion criteria can be selected for this clinical trial. Subjects who meet the following criteria can be selected for this clinical trial: 1. Before the start of the experiment, obtain the informed consent form approved by the ethics committee by the subjects or their legal representatives voluntarily; 2. Suspected infections caused by Gram-positive bacteria G+ based on clinical experience: sepsis, central nervous system infection, surgical trauma and other superficial secondary infections, pneumonia, lung abscess, empyema, etc., with the following symptoms/signs/experiments Two of the room inspections: a. Fever (underarm temperature >= 37.3 degrees C) b. Peripheral blood white blood cell count (WBC) > 9500/mm3 or = 75% c. Patients with G+ isolated from body fluid specimens and drug sensitivity test indicated sensitivity to norvancomycin/vancomycin; 3. For central nervous system infections, the pathogenic evidence of gram-positive bacteria infection should be obtained as much as possible during the treatment process. If it meets the clinical diagnostic criteria for central nervous system infections, it can be administered empirically; 4. Complete the relevant examination of renal function before medicationeGFR(Glomerular Filtration Rate)> 50mL/min/1.73m2; 5. Age >= 18 years old and <= 70 years old, no gender limit; 6. Female patients must meet: a. Menopause for at least 1 year, or b. Has been surgically sterilized, or c.Have fertility, but must meet the following conditions: The blood or urine HCG test was negative before the test Agree to use an approved contraceptive method (for example: oral contraceptives, spermicides and condoms, or intrauterine contraceptives) during the entire study period. 7. Able to follow the research protocol to complete the test.
Exclusion criteria
Exclusion criteria: Subjects who meet any of the following exclusion criteria are not allowed to enter this clinical trial: 1. Patients with mental and/or cognitive impairment, unable to sign informed consent and complete the scale; 2. Patients with a history of allergy to vancomycin or norvancomycin, teicoplanin, glycopeptide antibiotics, and aminoglycoside antibiotics; 3. Patients with deafness or other deafness caused by glycopeptide antibiotics, teicoplanin or aminoglycoside antibiotics; 4. Other glycopeptides (vancomycin, teicoplanin) or linezolid or daptomycin were used within 24 hours before enrollment; 5. The patient is in a painful state, is deeply unconscious, has no spontaneous breathing, or has severe heart, lung, liver or other organ dysfunction; 6. Pregnant women and lactating patients; 7. Any known disease that seriously affects the immune system, such as a history of human immunodeficiency virus (HIV) infection, or advanced malignant tumors of the blood system or solid organs, or splenectomy, etc. 8. Those who have a history of epileptic seizures, or mental illness that may affect the compliance of the program, or are at risk of suicide; or have a history of alcohol or illegal drug abuse; 9. Patients who must be treated with oto-kidney toxicity drugs, which may increase drug toxicity: aminoglycoside antibiotics, amikacin, tobramycin, platinum-containing antitumor drugs, cisplatin, etc.; and Nephrotoxic drugs: cyclosporine, etc.; 10. Patients with severely impaired renal function; 11. Active hepatitis or decompensated cirrhosis; 12. People who faint with needle and blood; 13. Cases that cannot be collected due to incomplete information; 14. The investigator believes that there may be any situation that increases the risk of subjects or interferes with clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| liver function;renal function; | — |
Countries
China
Contacts
Public ContactZhiqing Zhang
Outcome results
None listed