Postoperative pulmonary complications
Conditions
Interventions
experimential group:Optimal positive end expiratory pressure guided by driving pressure
control group:Positive end expiratory pressure in 5cmH2O
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. From December 2020 to December 2021, laparoscopic colorectal cancer radical surgery under general anesthesia in our hospital; 2. Risk score of postoperative pulmonary complications >= 26; 3. ASA grade I ~ III.
Exclusion criteria
Exclusion criteria: 1. Those who refused to participate in the experiment; 2. Patients younger than 18 years old; 3. Patients with neuromuscular junction transmission disorders; 4. BMI >= 30Kg/m2; 5. Patients who are mechanically ventilated or have severe cardiac or pulmonary complications or other diseases that may endanger the safety of the trial procedure, and who use pacemakers or implantable cardioverter defibrillators; 6. Pregnancy, tracheotomy, facial, neck or chest wall abnormalities that affect postoperative breathing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PPCs within 7 days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of sRAGE;Concentration of IL-6, IL-8, IL-10, TNF-a, CRP;mCPIS;Pulmonary dynamic compliance; | — |
Countries
China
Contacts
Public ContactKe An
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed