Effects of berberine hydrochloride on blood pressure and vascular endothelial function in patients with hypertension

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000039789

Enrollment

Unknown

Registered

2020-11-10

Start date

2020-11-01

Completion date

Unknown

Last updated

2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential Hypertension

Interventions

Group A:Healthy lifestyle intervention

Group B:Berberine hydrochloride tablets: 0.4g, 3 times/day, 3 months

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Essential hypertension (office blood pressure: systolic blood pressure 140-159 mmHg and/or diastolic blood pressure 90-99 mmHg); 2. 18 to 75 years old; 3. No drugs or dietary supplements that affect blood pressure and vascular endothelial function have been used in the past 3 months, mainly including antihypertensive, lipid-lowering, hypoglycemic drugs and natural plant extract antioxidants; 4. Individuals who voluntarily sign the consent form after being fully informed and understanding the purpose and procedure of the study, characters of the disease, drug effects, methods of related examinations, and potential risk/benefits of the study.

Exclusion criteria

Exclusion criteria: 1. Individuals with secondary blood pressure rise factors; 2. Individuals who are hypersensitive or intolerant to the drugs; 3. Individuals presenting severe constipation; 4. Individuals with severe heart disease, abnormal liver and kidney function, acute and chronic infections, autoimmune diseases and patients with any history of cancer; 5. Individuals with mental diseases who are not able to cooperate; 6. Pregnant women, women during breast-feeding period, or women with expect pregnancy; 7. Individuals with hemolytic anemia and glucose-6 phosphate dehydrogenase deficiency.

Design outcomes

Primary

Measure	Time frame
24-hour ambulatory blood pressure;Office blood pressure;Brachial artery blood flow-mediated vasodilation;Brachial ankle pulse wave velocity;	—

Secondary

Measure	Time frame
Number of circulating endothelial progenitor cells and endothelial microparticles;	—

Countries

China

Contacts

Public ContactJun Tao

The First Affiliated Hospital of Sun Yat-Sen University

taojungz123@163.com+86 20-87606191

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026