Carotid atherosclerosis
Conditions
Interventions
Sponsors
Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patients with carotid atherosclerotic plaques were diagnosed by color Doppler ultrasound; 2. hsCRP >= 2 mg/L; 3. Patients between 40 and 80 years old, regardless of gender; 4. Patients who can take medicine for a long time; 5. Patients who have informed consent and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Acute or subacute hemorrhage in plaque; 2.Plaque is calcified and fibrotic; 3.Can not do MRI(such as carrying a pacemakerdenturecardiac stent); 4.Patients with active ulcers and bleeding tendency who take anticoagulants (such as warfarin) for a long time; 5.Patients are using dual antiplatelet drugs; 6.Patients with serious arrhythmia, atrial fibrillation and heart failure; 7.Patients with severe liver, kidney, hematopoietic system, endocrine system, respiratory system, hypertension, infectious and non infectious inflammation, immune related and other primary diseases, whose liver function is more than 1.5 times higher than the upper limit of the normal value, and whose Cr is higher than the normal value; 8.Any other life-threatening or serious disease that cannot be treated for 12 months and thus affects the evaluation results; 9.Pregnant or lactating women, women with a recent pregnancy plan; 10.Patients with allergic constitution; 11.Other diseases or psychosis that may limit efficacy evaluation or patient follow-up in the opinion of researchers; 12.Patients who have participated in clinical trials of other drugs in the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum fiber cap thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume of Lipid-Rich Necrotic Core;Volume percentage of Lipid-Rich Necrotic Core;Carotid Atherosclerosis Score;Volume of Fiber cap;Volume percentage of Fiber cap;Volume of bleeding in plaque;Volume percentage of bleeding in plaque;Volume of plaque calcification;Volume percentage of plaque calcification;Vascular stenosis rate;Average value of vascular wall thickness;Maximum vascular wall thickness;Volume of vascular wall;Total vessel wall load (volume of vascular wall/total volume of blood vessels);Weight;Blood lipid;Blood glucose;Blood pressure;High-sensitivityC-reactive protein; | — |
Countries
China
Contacts
Public ContactWu Shengxian
Dongzhimen Hospital of Beijing University of traditional Chinese Medicine
Outcome results
None listed