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Screening of novel molecular biomarkers for sorafenib resistance in hepatocellular carcinoma and its early warning of sensitivity to regofinib

Screening of novel molecular biomarkers for sorafenib resistance in hepatocellular carcinoma and its early warning of sensitivity to regofinib

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000039762
Enrollment
Unknown
Registered
2020-11-08
Start date
2020-12-01
Completion date
Unknown
Last updated
2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HCC

Interventions

sensitive patients vs resistant patients:Nil

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The patients with HCC or cirrhosis confirmed by histology / cytology met the clinical diagnostic criteria of the American Association for the study of liver diseases (ahld); 2. Age >= 18 years; 3. ECoG physical status score 0 or 1; 4. BCLC stage C. Stage B is not suitable for radical surgery and / or local treatment; 5. has not received systemic systemic anti-tumor therapy for hepatocellular carcinoma; 6. according to the evaluation standard for solid tumor efficacy version 1.1, there is at least one measurable lesion or measurable lesion with definite progression after local treatment; 7. child Pugh score = 12; 9. sign the written informed consent, and be able to comply with the visit and related procedures stipulated in the program.

Exclusion criteria

Exclusion criteria: 1. To investigate the clinical features of fibrolamellar hepatocellular carcinoma, sarcomatoid hepatocellular carcinoma and cholangiocarcinoma confirmed by histology / cytology; 2. to have a history of hepatic encephalopathy or liver transplantation; 3. to be infected with acute or chronic active hepatitis B or hepatitis C; 4. to have central nervous system metastasis; to pregnant and lactating women; 5. to metastatic cancer or to merge with other tumors.

Design outcomes

Primary

MeasureTime frame
Liver tumor size;

Countries

China

Contacts

Public ContactQin Li

Shanghai General Hospital

liqin0626@hotmail.com+86 13918516282

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026