Atrial Fibrillation
Conditions
Interventions
pulmonary vein isolation (Group PVI):cryoballoon ablation of pulmonary vein isolation
cryoballoon ablation of roof line combined with pulmonary vein isolation (Group RL):cryoballoon ablation of roof line combined with pulmonary vein isolation
Sponsors
Department of Cardiovasology, Changhai Hospitai
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Symptomatic non-valve atrial fibrillation, and symptoms appear when there is electrocardiograph, holter monitor or random electrocardiograph, with duration between 7 days and 3 years. 2. Refractory to at least one class I or class III antiarrhythmic drug. 3. Age between 18 and 80 years old. 4. Patients who are aware of the advantages and disadvantages of radiofrequency ablation and cryoballoon ablation. 5. Participants or legal representatives of whom understand and have the willingness to write informed consent and participant in the trial.
Exclusion criteria
Exclusion criteria: 1. Thrombosis in the left atrium or left atrial appendage; 2. Left atrial diameter over 50mm; 3. With high possibility of bleeding or contraindication of anticoagulant drugs; 4. With a history of stroke or myocardial infarction in 3 months; 5. Uncontrolled hyperthyroidism; 6. Pregnancy; 7. The expected lifetime less than one year; 8. Cryoglobulinemia; 9. Severe lung function decline (with a history of COPD); 10. Abnormal thyroid function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival rate with no atrial fibrillation; | — |
Countries
China
Contacts
Public ContactCao Jiang
Department of Cardiovasology, Changhai Hospitai
Outcome results
None listed