Mild Cognitive Impairment(aMCI)
Conditions
Interventions
Optimized rTMS group:Optimized rTMS
HF rTMS group :HF rTMS
Sham rTMS group :Sham rTMS
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Right-handed, 50-85 year old Chinese; 2. Voluntary signing of informed consent; 3. Meet the safety standard of TMS treatment; 4. Patients diagnosed with MCI: All subjects underwent a routine clinical physical examination by a physician at the Memory clinic, and complete a full set of neuropsychological tests, including: overall cognitive function assessment (MMSE and MoCA-B), memory function evaluation (Hopkins verbal learning test, Wechsler logical memory test) and executive function evaluation (Trail Making Test A and B), language function evaluation (Boston naming test and Verbal fluency test-vegetables), visuospatial function evaluation (Rey-Osterrieth Complex Figure Test copy and recall), instrumental daily life capability assessment (IADL), clinical dementia rating scale (CDR) evaluation. Finally, the memory outpatient doctor made a diagnosis of whether the patient belongs to MCI combined with the medical history, physical examination, auxiliary examination (including structural MRI), etc. The diagnostic criteria referring to the results of neuropsychological test battery are: 1) a chief complaint of cognitive decline, or cognitive decline as reported by an caregiver; 2) MMSE score, 1SD); (2) more than 2 cognitive domains were impaired with one indicator; (3) IADL has more than one item scored to more than one point.
Exclusion criteria
Exclusion criteria: 1. Have severe visual, hearing, aphasia and other physical diseases and cannot successfully complete the neuropsychological test; 2. Have a history of other neurological or psychiatric disorders (such as dementia, stroke, Parkinson's disease, epilepsy, major depression, etc.), cardiovascular disease, diabetes, thyroid disease, vitamin B12 deficiency, history or evidence of substance abuse; 3. Have contraindications with MRI scanning; 4. Structural MRI indicated lesions such as new lesions or space-occupying lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological test battery ;Event related potential (ERP): N2PC, CDA; | — |
Countries
China
Contacts
Public ContactYunxia Li
Department of Neurology, Tongji Hospital
Outcome results
None listed