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The efficacy and safety of furosemide for prevention of intradialytic hypotension in hemodialysis patients: protocol for a multicenter randomized controlled trial

The efficacy and safety of furosemide for prevention of intradialytic hypotension in hemodialysis patients: protocol for a multicenter randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000039724
Enrollment
Unknown
Registered
1990-01-01
Start date
2021-06-30
Completion date
Unknown
Last updated
2021-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hemodialysis

Interventions

Furosemide treatment group:Furosemide treatment
Control group:Blank control

Sponsors

Department of Nephrology, West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Participants who have been treated with HD three times a week for more than 3 months, medically stable, with residual renal function (RRF) of more than 200 ml urine output per day (based on a 24-hour urine collection, measured by a 200 ml measuring cup), and consent to participate in the study.

Exclusion criteria

Exclusion criteria: Participants with systolic blood pressure <= 100mmHg, a history of liver cirrhosis or concurrent liver impairment, experienced congestive heart failure (ejection fraction <= 50%), acute myocardial infarction or stroke in the preceding six months; used loop diuretics in the preceding one month; plan to receive a kidney transplant during the study period, or any other condition that the research staff judged as hard to complete, or comply with, or otherwise unsuitable for the study.

Design outcomes

Primary

MeasureTime frame
the rate of symptomatic IDH;

Secondary

MeasureTime frame
Admission rate;All cause mortality;Cardiac mortality;Cardiovascular events;Episode of frank (or suspected) sepsis;Interdialytic weight gain;IDH-related nursing interventions;

Countries

China

Contacts

Public ContactZhang Ling

Sichuan University West China Hospital

zhanglingcrrt@163.com+86 18980601985

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026