Tuberculosis
Conditions
Interventions
Gold Standard:Tuberculosis culture
Index test:The 
VAS 
the 
redness 
and 
induration 
of 
duration 
microneedle 
test 
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
Male
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Volunteers voluntarily agreed to participate in this study, aged 18-65 years old. Participants should know their BCG immunity and whether they have tuberculosis infection or history. 2. Active tuberculosis infection group: with clinical symptoms of tuberculosis (cough >= 2 weeks, continuous fever, night sweats, weight loss, etc.), excluding other pulmonary diseases, and meeting one of the following diagnostic criteria: (1) PPD was strongly positive; (2) The pathogen test was positive; (3) Imaging diagnosis: common X-ray film, CT, MRI or ultrasound suggested that active tuberculosis might occur; (4) Tuberculosis was diagnosed by pathological tissue or molecular pathology; 3. Latent infection tuberculosis group: no clinical symptoms of tuberculosis, and meet the following diagnostic criteria: (1) PPD >= 5mm; (2) IFN - ? release test (IGRAs) was positive; (3) The pathogen test was negative; (4) Imaging diagnosis: X-ray, CT, MRI or ultrasound showed that tuberculosis was negative; 4. Control group: BCG immunized people and healthy people with negative IGRAs test.
Exclusion criteria
Exclusion criteria: 1. Patients who have recently received antituberculosis treatment take anticoagulants or have coagulation dysfunction; 2. Patients with primary or secondary immunodeficiency, including HIV, long-term steroid use and patients with autoimmune diseases; 3. Patients with malignant tumor, language dysfunction, mental system disease and other serious diseases; 4. Patients participating in other clinical trials; 5. Patients who are considered unsuitable for clinical trials for other reasons by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the redness and induration of the skin and duration time; | — |
Countries
China
Contacts
Public ContactWei Wang
Shenzhen Second People's Hospital
Outcome results
None listed