Major Depressive Disorder
Conditions
Interventions
Experimental group:Before anesthesia, routine mask was used to denitrogen oxygen, 0.5mg/kg atropine was given, and then 0.5mg/kg S-ketamine and 1mg/kg succinylcholine were induced by anesthesia
Control group:Before anesthesia, routine mask was used to denitrogen oxygen, 0.5mg/kg atropine was given, and then 2mg/kg propofol and 1mg/kg succinylcholine were induced by anesthesia
Sponsors
Tongji Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Make clear the object of MDD diagnosis (accord with tcd-10. Diagnosis of depressive episode (F32) or recurrent depression (f33)); 2. People aged 18-65, regardless of gender; 3. ASA grade: I ~ II; 4. Subjects with primary school education or above or who understand the content of the scale; 5. Obtain the informed consent of the patient and / or the legal guardian and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe physical diseases, such as cardiovascular and cerebrovascular diseases, intracranial hypertension, respiratory diseases and severe fractures, as well as patients with poorly controlled or untreated hypertension (systolic / diastolic blood pressure more than 180 / 100mmhg), glaucoma, aneurysm, or cerebral vascular malformation; 2. Patients with foreign body: pacemaker, intracranial electrode, etc.; 3. Patients with history of epilepsy; 4. Previous history of anesthesia allergy; 5. Pregnant and lactating women; 6. Patients with bipolar disorder or other mental diseases or mental retardation; 7. Patients with a history of drug abuse or dependence; 8. Subjects with hearing and speech communication disorder; 9. Other reasons why the researchers think it is not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale(HAMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| QIDS-SR16;EEG;fMRI;BDNF; | — |
Countries
China
Contacts
Public ContactXiaoqing Zhang
Tongji Hospital Affiliated to Tongji University
Outcome results
None listed