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Effect of electroacupuncture combined with tACS on working memory and executive function in patients with mild cognitive impairment and its mechanism

Effect of electroacupuncture combined with tACS on working memory and executive function in patients with mild cognitive impairment and its mechanism

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000039631
Enrollment
Unknown
Registered
2020-11-03
Start date
2020-11-04
Completion date
Unknown
Last updated
2021-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment

Interventions

Sponsors

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients meeting the core clinical diagnostic criteria of MCI; 2. Patients with age >= 50 years old and 12 years) 19-26 points indicate mild abnormality. 5. Patients with clinical dementia rating scale score <= 0.5 showed no dementia or suspected dementia; 6. Patients with no obvious disorder of activities of daily living according to Barthel index; 7. Subjects with GDS <= 6 showed no depression; 8. Subjects who can tolerate 3 hours of assessment and intervention; 9. The subjects who voluntarily participated in this study and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with local skin infection, ulcer scar or over sensitivity to acupuncture; 2. Patients with severe hemorrhagic diseases and coagulation disorders; 3. Patients with a history of epilepsy or seizures; first degree relatives have a history of epilepsy 4. Patients with metal implants in the body or head (except stomatology); patients with implanted pacemaker defibrillator and cochlear implant drug pump; patients with implanted pacemaker defibrillator and cochlear implant drug pump; 5. Patients with recurrent headache who have no response to drug treatment due to unknown reasons; 6. Patients with skull fracture and / or severe head injury; history of head and / or brain surgery; 7. Patients with severe heart disease and increased intracranial pressure; 8. Patients taking tricyclic antidepressants, antipsychotics and other drugs to reduce seizure threshold; 9. Patients with other diseases or history affecting cognitive function; 10. Patients with depression, schizophrenia and other mental diseases; 11. Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
electroencephalography;

Secondary

MeasureTime frame
eye movement;

Countries

China

Contacts

Public ContactChunlei Shan

Shanghai University of Traditional Chinese Medicine

534489132@qq.com+86 13816215058

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026