Gastroesophageal Reflux Disease
Conditions
Interventions
Test
Gold Standard:Endoscopy and esophageal pH monitoring
Index test:Short-course 
Vonoprazan 
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-70 years; 2. Patients with typical symptoms of gastroesophageal reflux disease: heartburn and / or reflux, symptoms lasting more than 3 months, at least twice a week; 3. The subjects who sign the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Patients with gastrointestinal ulcer or malignant tumor found under endoscopy; 2. Patients with digestive tract operation history; 3. Patients with esophageal motility disorders, such as achalasia, etc; 4. Patients with a history of other serious diseases, such as severe cardiopulmonary disease, diabetes or rheumatic diseases, renal failure or liver failure; 5. Subjects who had taken anti ulcer and anti reflux drugs within 7 days before enrollment (except for anti acid drugs or alginate), and those who refused to stop using such drugs during the study period; 6. Patients taking NSAIDs; 7. Subjects who used any experimental drugs within 16 weeks before enrollment or during the study period; 8. Patients allergic to vonora; 9. Subjects of lactation or pregnancy; 10. The subjects of alcohol or drug abuse, and the poor compliance caused by any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity of the 4-week P-CAB test;The specificity of the 4-week P-CAB test for the diagnosis of GERD; | — |
Countries
China
Contacts
Public ContactMinhu Chen
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed