Postoperative cognitive dysfunction, postoperative pulmonary complications
Conditions
Interventions
Group P:Penehyclidine hydrochloride 0.04mg /kg, Half of penehyclidine was injected intravenously 10 minutes before anesthesia, and the other half was injected immediately after cardiopulmonary bypass
Group D:Dexmedetomidine is continuously pumped for 0.5 ug/kg/h
Group PD:Half of penehyclidine was injected intravenously 10 minutes before anesthesia, and the other half was injected immediately after cardiopulmonary bypass
Dexmedetomidine is continuously pumped for 0.5 ug/kg/h.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 20-65 years; 2. Subjects weighing 40-66 kg (BMI 18.5-23.9); 3. ASA II ~ II I objects; 4. Subjects of cardiac function classification I ~ II.
Exclusion criteria
Exclusion criteria: 1. Patients with mini mental state examination (MMSE) <= 23 points, 2. Glaucoma patients; 3. Patients with prostatic hypertrophy; 4. Patients with severe vision or hearing impairment; 5. Illiteracy and / or communication difficulties related to pronunciation or dialect, 6. Patients with acute or chronic infectious diseases, 7. Patients taking anti-inflammatory drugs, immunosuppressants or psychotropic drugs 8. Patients with lung, brain, liver, kidney and other organ diseases, 9. Patients with endocrine system diseases, 10. Patients with stroke or other neuropsychiatric diseases in the first 6 months, 11. Patients with history of hyperlipidemia, carotid atherosclerosis or stenosis, 12. Patients with poor preoperative pulmonary oxygenation, finger pulse oxygen < 90%, pure oxygen inhalation, finger pulse oxygen < 95%; 13. Patients who refuse or are discharged accidentally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P (A-a) DO2;Oxygenation index (OI);respiratory index (RI);Respiratory parameters (tidal volume, respiratory rate, airway peak pressure, mean airway pressure);Extubation time;ICU staying;Secondary intubation rate;Postoperative pulmonary complications;Cognitive status;Delirium assessment;arterial blood gas analysis;Blood gas analysis of the bulb of right internal jugular vein;lactic acid;blood sugar;Arterial jugular bulb oxygen content difference;cerebral extraction of oxygen;Regional cerebral oxygen saturation;S100ß;Neuron specific enolase (NSE);Glial fibrillary acidic protein (GFAP);surfactant-associated protein-A (SP-A);Tumor necrosis factor - a (TNF -a);Interleukin-6 (IL-6);C-reactive protein (CRP);heart rate;Invasive blood pressure;mean arterial pressure;Central venous pressure;Pulse oxygen saturation (SPO2);Urine output; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiopulmonary bypass time;Operation time;Aortic clamping time;Vena cava occlusion time;Minimum body temperature;Postoperative complications;The length of hospital stay;Numerical Rating Scale (NRS); | — |
Countries
China
Contacts
Public ContactYizhi Lu
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed