Central pruritus
Conditions
Interventions
trial group:In the routine treatment of the anesthesiology department, an intravenous injection of 0.5µg/kg Nalmefene injection was additionally given
control group:routine treatment
Sponsors
Zhongshan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. To participate voluntarily, the patient himself understands and signs or his immediate family members sign the informed consent form; 2. Age: 18-80 years old; 3. Patients undergoing surgical operation and voluntary epidural analgesia during and after surgery; 4. Indications for epidural analgesia: normal coagulation function; platelets >= 75 x 10^9/L; 5. For patients with itching on the day of surgery and the first day after surgery, exclude other related factors.
Exclusion criteria
Exclusion criteria: 1. Contraindications for epidural analgesia: hypocoagulation (abnormal coagulation function or platelets < 75 x 10^9/L); puncture site sensation or bacteremia can cause epidural infection; oral anticoagulation during perioperative period and Antiplatelet drugs; patients with hypovolemia or shock; uncooperative persons such as psychosis and severe neurosis; 2. Patients with past symptoms of itching: patients with a history of skin diseases, gout, rheumatic diseases; 3. Patients with perioperative allergies or previous history of allergic diseases, allergic to antibiotics, anesthetics, latex, etc.; 4. The puncture site is unsure whether the epidural operation is successful due to trauma, deformity, implant, lower back pain, etc.; 5. Patients who have received allogeneic blood transfusion in the past month; 6. Serious complications occurred during and after the operation; 7. Patients who lack expression ability or have obstacles to autonomous movement of limbs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Itching score; | — |
Countries
China
Contacts
Public ContactFang Fang
Zhongshan Hospital of Fudan University
Outcome results
None listed