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Clinical application of transpulmonary pressure monitoring to guide mechanical ventilation in patients with ARDS

Clinical application of transpulmonary pressure monitoring to guide mechanical ventilation in patients with ARDS

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000039586
Enrollment
Unknown
Registered
2020-11-01
Start date
2019-04-01
Completion date
Unknown
Last updated
2021-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome

Interventions

Transpulmonary pressure group:Transpulmonary pressure titration of PEEP
ARDSnet group:Titrating PEEP according to ARDSnet table

Sponsors

The Third Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged > 16 years; 2. Invasive ventilator-assisted ventilation is required, and the expected ventilation time is more than 72 hours; 3. Meet the diagnostic criteria defined by ARDS Berlin in 2012; 4. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: Acute myocardial infarction, acute renal failure, pregnant women,AECOPD, pulmonary interstitial fibrosis, definite valvular heart disease and heart failure.

Design outcomes

Primary

MeasureTime frame
28-Day mortality;Hospitalization time;Mechanical ventilation time;—

Secondary

MeasureTime frame
Pplat;Transpulmonary pressure;Lung compliance;Oxygenation index;Pulmonary vascular permeability index;Extravascular lung water index;Vascular permeability related factors;APACHE II score;SOFA score;—

Countries

China

Contacts

Public ContactZhiyong Wang

The Third Hospital of Hebei Medical University

wzyphd@126.com+86 18533112993

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026