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Efficacy and safety of polymyxin B in the treatment of Carbapenem resistant gram negative bacterial infection: a multi-centered and retrospective cohort study

Efficacy and safety of polymyxin B in the treatment of Carbapenem resistant gram negative bacterial infection: a multi-centered and retrospective cohort study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000039584
Enrollment
Unknown
Registered
2020-11-01
Start date
2020-11-10
Completion date
Unknown
Last updated
2021-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carbapenem resistant gram-negative bacterial infection

Interventions

study cohort:Nil

Sponsors

Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) patient aged at least 18 years; (2) hospitalized patients; (3) clinical diagnosis of infection, and etiology confirmed carbapenem resistant gram-negative bacteria; (4) patients visited after January 2018.

Exclusion criteria

Exclusion criteria: (1) incomplete medical records; (2) unable to evaluate the primary endpoint.

Design outcomes

Primary

MeasureTime frame
30-day all cause mortality;serum creatinine;plasma concentration of polymyxin B;—

Secondary

MeasureTime frame
clinical efficacy;clinical cure rate;microbial clearance;—

Countries

China

Contacts

Public ContactYU Yunsong

Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University

yvys119@163.com+86 13805790432

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026