Asthma
Conditions
Interventions
Gold Standard:Clinical outcome
combined 
with 
biomarkers 
of 
inflammation
Sponsors
Chongqing Medical University Affiliated Children's Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 5 Years
Inclusion criteria
Inclusion criteria: (1) Children aged 3 to 5 years old; (2) Three or more wheezing episodes; (3) Asthma diagnosed by a pediatric pulmonologist.
Exclusion criteria
Exclusion criteria: (1) Mental retardation, cardiac anomalies, congenital malformations, other diseases of the lungs/airways, and Crohn's disease or rheumatic arthritis; (2) The inability to perform lung function tests or inflammatory biomarker measurements; (3) A history of lower respiratory tract infection within 2 weeks before the tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma incidence at school age;SEN, SPE, ACC, AUC of ROC, PPV, NPV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization;Emergency department visit;Intensive care unit admission;Systemic steroid use;Frequency of exacerbations;Asthma control level;Life quality;Spirometry;Impulse oscillometry;Fraction of exhaled nitric oxide;Blood eosinophil;sIgE;Clara cell secretory protein in serum; | — |
Countries
China
Contacts
Public ContactZhengxiu Luo
Chongqing Medical University Affiliated Children's Hospital
Outcome results
None listed