Intestinal disease
Conditions
Interventions
Dexmedetomidine group:1. Intravenous infusion of dexmedetomidine 0.4µg/kg within 10 minutes before induction
2. Continuous pumping of dexmedetomidine 0.5µg/kg/h during the operation until the end of the operation
Lidocaine group:1. Inject lidocaine 1 mg/kg intravenously within 10 minutes before induction
2. Inject lidocaine 2 mg/kg/h continuously during the operation until the end of the operation
Control group:1. Inject 20ml of saline intravenously within 10 minutes before induction
2. Inject 0.2mlg/kg/h of saline continuously during the operation until the end of the operation
Sponsors
Department of Anesthesia, the First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Elderly patients undergoing elective laparoscopic colorectal surgery, aged >= 65 years, regardless of gender.
Exclusion criteria
Exclusion criteria: (1) Past chronic pain or long-term use of analgesics; (2) History of various types of heart block; (3) Those with severe liver and kidney dysfunction; (4) History of allergy to various analgesic drugs; (5) The operation causes failure or severe changes in the patients circulation and breathing, and ICU supportive treatment is required after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative bowel function recovery;Concentrations of norepinephrine, epinephrine, ACTH, and cortisol in serum;The amount of analgesic drugs used during and after surgery; | — |
Countries
China
Contacts
Public ContactKe Wei
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed