Influenza
Conditions
Interventions
Intervention group:Vaccinated in the morning (9 am-11 am GMT+8)
Control group:Vaccinated in the afternoon (3 pm-5 pm GMT+8)
Sponsors
The First Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Permanent residents in Guangzhou (living in Guangzhou in the past six months); 2. People who aged 50-60 and 65-75 years old.
Exclusion criteria
Exclusion criteria: 1. Patient with autoimmune disease; 2. Patient with immunodeficiency syndrome; 3. Patient with malignant tumor; 4. Patient who takes medicine affecting the immune function, such as immunosuppressant agents or immunopotentiators or glucocorticoids (>=10mg prednisone or other equivalent glucocorticoids) within one month before enrollment; 5. Those who are allergic to any of the ingredients in the vaccine, such as excipients, eggs, egg protein, neomycin, formaldehyde and octoxynol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| antibody titers of A/H1N1, A/H3N2 and B strain one-month post-vaccination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune cell phenotype;cytokines;Laboratory Confirmed Influenza;Influenza-like Symptoms;Patient Reported Outcome;the level of steroids; | — |
Countries
China
Contacts
Public ContactSui Peng
The First Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed