Parkinson's Disease
Conditions
Interventions
contral group:repetitive transcranial magnetic stimulation with sham coil
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Idiopathic Parkinson's Disease and diagnosed according to the 2015 Movement Disorder Society (MDS) clinical diagnostic criteria; 2. One or more situation as follow: have 1 or more pain with the VAS more than 3 and last at least 3 month; have one or more kind of sleep disorder; have freezing gait; 3. Patients with stable anti parkinsonian therapy for >= 2 weeks, and stay on their medication regimens throughout the trial; 4. Patients with stable non steroidal anti-inflammatory drugs and other analgesic drugs therapy for >= 16 weeks, and stay on their medication regimens throughout the trial; 5. The brain CT/MRI has no special change; 6. Patients with Mini–Mental State Examination scores > 22; 7. Patients and their families who sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with conditions other than PD that can cause pain, such as diabetes, herpes infection, long-term special drugs or heavy drinking, stroke, spinal cord disease; 2. Patients with severe depression or mental disorders; 3. Patients with histories of intracranial organic lesions or traumatic brain injury; 4. Patients with severe organic diseases such as heart, liver and kidney; 5. Patients with claustrophobia, implantable devices such as pacemaker, history of epilepsy, who can not complete MRI examination or receive rTMS treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| numerical rating scale;polysomnography;Resting-state brain functional MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| King's Parkinson's Pain Scale; | — |
Countries
China
Contacts
Public ContactChunfeng Liu
The Second Affiliated Hospital of Soochow University
Outcome results
None listed