Chronic Atrophic Gastritis
Conditions
Interventions
Treatment:Lotus Leaf Treatment
Placebo:Placebo
Sponsors
Tsinghua University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 70 years. 2.Patients with chronic atrophic gastritis by endoscopic and pathology.
Exclusion criteria
Exclusion criteria: 1.Patients with gastric ulcer,gastric polyps,gastroesophageal reflux or history of stomach surgery. 2.Having taken glucocorticoid or non-steroidal anti-inflammatory drugs in the past three months. 3.Patients with cardiovascular diseases,respiratory system, digestive system or endocrine systems . 4.Significant renal or hepatic insufficiency (defined as a serum creatinine concentration, alanine aminotransferase, or aspartate minotransferase value that is twice greater than the upper limit of normal). 5.Allergic to lotus leaf related food or drug. 6.Pregnancy or to be pregnancy;lactating women. 7.Other conditions that render outcomes or follow-up unlikely to be assessed. 8.Tumors or other serious life-threatening illness,expected lifetime less than 12 months. 9.Having participated in other drug trials in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the Correa scores between baseline and 12 months follow-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in the Correa scores between baseline and 6 months follow-up;Change of OLGA\OLGIM stages in 6 months and 12 months.;Difference in the updated Sydney system scores in 12 months;Appearance rate of high-grade dysplasia;Change of serum level of pepsinogen and Gastrin;Rate of symptom improvement; | — |
Countries
China
Contacts
Public ContactLi Shao
Tsinghua University
Outcome results
None listed