cognitive dysfunction
Conditions
Interventions
Experimental group:Intraoperative infusion of lidocaine
Control group:Saline infusion with the same volume
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged over 60 years; 2) With intrathecal anesthesia; 3) ASA I or II; 4) Preoperative MMSE score >= 27; 5) Postoperative hospitalization more than 5 days; 6) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) ASA III or IV; 2) Refused to participate; 3) anesthesia method was changed; 4) preoperative MMSE score < 27; 5) congestive heart failure; 6) allergic to local anesthetics; 7) preexcitation syndrome; 8) Adam-Stoke syndrome; 9) severe heart block; 10) severe myocardial injury; 11) renal failure and liver failure; 12) hypovolemic shock; 13)previous cognitive, mental or central nervous system disorders; 14) severe language or hearing impairment; 15) malignant hyperthermia; 16) porphyria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-6;S-100ß;Interleukin-10; | — |
Countries
China
Contacts
Public ContactWangning Shangguan
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed