Pharmacokinetics
Conditions
Interventions
experimental group:1mg/kg esketamine intravenous injection
Sponsors
Women and Children's Hospital, School of Medicine, Xiamen University
Eligibility
Sex/Gender
All
Age
2 Years to 5 Years
Inclusion criteria
Inclusion criteria: 1. ASA score ranged from I to II; 2. Aged 2 to 5 years pediatric patient; 3. Weight 9.0 to 20.0 kg; 4. Operation time 24 h; 5. Patient is undergoing hypospadias surgery or lower extremity surgery; 6. To be able to good communication with researchers, and signed a written informed consent.
Exclusion criteria
Exclusion criteria: 1. The pediatric patient or the guardian or family members refuse; 2. History of fever, cough, sputum and asthma within 14 days before surgery; 3. Examination before anesthesia shows obvious secretions in the nasal cavity; 4. Severe heart, liver and kidney dysfunction; 5. Pediatric patient with congenital or genetic diseases; 6. Allergy to narcotic drugs; 8. Unable to cooperate with the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the plasma concentration of esketamine;the plasma concentration of S-demethylation ketamine; | — |
Secondary
| Measure | Time frame |
|---|---|
| BP, HR, RR, SpO2;recovery time;restlessness during recovery;adverse reaction;body movement; | — |
Countries
China
Contacts
Public ContactLiao Yicong
Women and Children's Hospital, School of Medicine, Xiamen University
Outcome results
None listed