Hemodynamic change
Conditions
Interventions
S-Ketamine group:S-ketamine 0.1mg/kg preanalgesia, 0.5mg/kg general anesthesia induction
sufentanil group:Sufentanil 0.1ug/kg for advanced analgesia and 0.1mg/kg for general anesthesia induction
Sponsors
Shanghai Sixth People's Hospital Haikou Orthopedics and Diabetes Hospital in Haikou
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-II; Ages 15-70 years; 2. No anaesthesia contraindications; 3. All lower extremity orthopaedic surgery patients; 4. Informed and consented to sign the consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to experimental drugs; 2. Serious risk of increased blood pressure or intracranial pressure; 3. Hypertensive patients (quiet blood pressure > 170/100mmHg); 4. Hyperthyroidism; 5. Serious functional insufficiency of important organs; 6. Patients with significant ischemic heart disease; 7. Sinus tachycardia; 8. Controlled antihypertensive surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic changes after induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of dizziness and headache;Incidence of nausea and vomiting;Incidence of respiratory depression;Adverse events within a week;satisfaction; | — |
Countries
China
Contacts
Public ContactXing Xiuhua
Shanghai Sixth People's Hospital, Haikou Orthopedics and Diabetes Hospital in Haikou
Outcome results
None listed