Lung disease
Conditions
Interventions
dexmedetomidine group:Intravenous infusion of dexmedetomidine (0.8 g·kg-1·h-1) for 10min before anesthesia induction, followed by continuous infusion at a rate of 0.4 g·kg-1·h-1 for 30min before the e
lidocaine group:Intravenous lidocaine 1.0mg·kg-1·h-1 was injected before anesthesia induction for 10min, and then the infusion was continued at a rate of 1mg·kg-1·h-1 for 30min before the end of the o
control group:Before anesthesia induction, normal saline was injected intravenously for 10min, and then the infusion was continued at the rate of 1mg·kg-1·h-1 for 30min before the end of the operation
Sponsors
Department of Anesthesia, the First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. All patients had unilateral lobar tumors with tumor diameter < 5 cm; 2. Optional thoracoscopic radical resection of lung cancer under general anesthesia; 3. No other complications before surgery, no history of radiotherapy and chemotherapy; 4. Age 65~80 years old, regardless of gender, BMI <= 30 kg/m2; 5. According to the New York Heart Association (NYHA) classification, cardiac function grade I~II; 6. Patients volunteered to participate in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Non-thoracoscopic lobectomy; 2. Operation time > 5 hours; 3. Sinus bradycardia or atrioventricular block; 4. the past use of immunosuppressants and recent chemoradiotherapy; 5. Local anesthetic allergy; 6. Liver and kidney dysfunction; 7. Diabetes; 8. Epilepsy and accompanied by mental, cognitive dysfunction and long-term stress stimulation or psychological disorders; 9. Blood transfusion patients; 10. Patients taking non-steroidal anti-inflammatory or steroid drugs, angiotensin-converting enzyme inhibitors, or bronchodilators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma cortisol, adrenaline, norepinephrine, IL-6, TNF-a, C-reactive protein;Short-term postoperative prognosis; | — |
Countries
China
Contacts
Public ContactKe Wei
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed