post-stroke depression
Conditions
Interventions
DLPFC group:Navigation-guided iTBS stimulation (1200 pulses)
DMPFC group:Navigation-guided iTBS stimulation (1200 pulses)
Sham group:Navigation-guided iTBS stimulation (1200 pulses
False stimulation coils)
Sponsors
China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients with cerebral hemorrhage or cerebral infarction who meet the diagnostic criteria of the 2018 edition of the "Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke" or the 2019 edition of the "Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage" formulated by the Neurological Branch of the Chinese Medical Association and confirmed by head CT or MRI, the course of the disease is between 1-12 months; (2) According to the American Diagnostic and Statistical Manual of Mental Disorders (DSM-V), patients with post-stroke depression are classified as "depressive disorders due to other physical diseases"; (3) Hamilton Depression Scale (HAMD-24) total score= 14 points; (4) Age 18-70 years old; (5) Patients and their families are aware of the examination procedures of this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with severe aphasia, dysarthria and impaired consciousness who cannot cooperate with the examination; (2) Those with hearing loss and severe cognitive impairment who cannot cooperate with the scale assessment; (3) History of drug/alcohol abuse, epilepsy, depression, bipolar disorder, mania, history of post-traumatic stress disorder; (4) Patients with tumors, other serious neurological diseases, and unstable central nervous system symptoms; (5) Contraindications to magnetic resonance examination include metal foreign bodies in the body, claustrophobia, etc.; (6) Contraindications to transcranial magnetic stimulation include history of epilepsy, epileptiform changes in EEG, and intracranial metal foreign bodies, cochlear implants and other electronic devices implanted in the body; (7) Women who are pregnant or planning to become pregnant; (8) Those who are currently participating in other clinical research trials; (9) Those who have received other non-invasive brain stimulation treatments in the past 3 months, such as transcranial magnetic stimulation, transcranial direct current stimulation, etc; (10) Those who cannot cooperate with treatment or examination for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Beck Depression Self-rating Scale; | — |
Countries
China
Contacts
Public ContactZhang Hao
China Rehabilitation Research Center
Outcome results
None listed