Sepsis related acute kidney injury
Conditions
Interventions
experimental group:Early RRT under the guidance of electronic early warning system
control group:Standard RRT according to traditional renal replacement indications
Sponsors
Tianjin First Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: According to Sepsis3.0 and KDIGO scores, there were a total of 200 adult patients (age >=18 years) admitted to ICU ward who met both criteria.Sepsis 3.0, sepsis is defined as life-threatening organ failure resulting from the body's uncontrolled response to infection. Sepsis 3.0 = infection+SOFA >= 2. KDIGO standard and grading, AKI was defined as:(1) increased serum creatinine (Scr) >= 26.5umol/L within 48h;(2) Scr increased by 1.5 times or more than the base value within 7 days;(3) Reduced urine output (& LT;0.5ml/kg/h) and the duration is above 6h. Sepsis is diagnosed according to Sepsis3.0, a life-threatening organ dysfunction caused by the body's uncontrolled response to infection.Organ dysfunction was assessed by SOFA score.Diagnostic criteria for septic AKI: both sepsis and acute kidney injury were met, and non-infective causes of acute kidney injury were excluded (such as urinary tract obstruction, renal toxic drug use, and renal injury caused by contrast agents).
Exclusion criteria
Exclusion criteria: Chronic nephropathic disease (CKD stage4, STAGe5) or renal replacement therapy prior to ICU admission; After kidney transplantation; Less than 72h in ICU; Non-infective causes of acute kidney injury (e.g., urinary tract obstruction, nephrotoxic drug use, and contrast media).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the ratio of kidney reserve;28 day motality;hospital stay;urinary TIMP2·IGFBP7; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time of mechnical ventilation;the time without mechincal ventilation;the ratio of renal replacement therapy; | — |
Countries
China
Contacts
Public ContactWang Jingjing
Intensive Care Unit of Tianjin First Center Hospital
Outcome results
None listed