Liver and gallbladder surgery
Conditions
Interventions
control group:normal saline
experimental group:S(+)-ketamine
Sponsors
Tangshan Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 60;Elective liver and gallbladder surgery ASA rating I ~ II level; Weight 45 ~ 85 kg; Height 150 ~ 185 cm;Anesthesia duration >= 2 hours; Intravenous controlled analgesia pump was used after operation.
Exclusion criteria
Exclusion criteria: 1. Those with incomplete clinical examination data and researchers think it is inappropriate to participate in this study. 2. Hypertensive patients whose blood pressure is not satisfactorily controlled by antihypertensive drugs; 3. Patients with water and electrolyte disturbances, severe atrioventricular block and severe cardiac insufficiency; 4. Pregnant or lactating women; 5. Patients with diseases of the blood system, respiratory system, digestive system and endocrine system caused by other diseases, as well as mental disorders and other diseases cannot cooperate with others; 5. Patients with drug intolerance or allergy are known in this study. 6. Those who have a history of sedative and hypnotic drug use and a history of long-term alcohol and drug abuse before operation; 7. Preoperative ecg indicated heart rate (HR)& LT; 8. 60 times /min or & GT;100 times /min; 9. Patients with peripheral vascular diseases, recent use of vasoactive drugs, antidepressants and painkillers; 10. Extreme mental stress, other accidents and the use of blood products during the operation; 11. Have a history of brain injury, intracranial hypertension, cerebral aneurysms, cerebrovascular accidents and central nervous system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, heart rate, blood oxygen saturation, and BIS;VAS pain score;The dosage of analgesics;The propofol dosage of BIS under 60 cents;Ramsay sedation score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of intraoperative and postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactYanrong Xu
Department of Anesthesiology, Tangshan Central Hospital
Outcome results
None listed