The neural mechanism of rTMS modulation in SCA3 based on cerebellum-neostraitum-cortical circuit

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000039434

Enrollment

Unknown

Registered

2020-10-28

Start date

2020-11-01

Completion date

Unknown

Last updated

2021-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hereditary Spinocerebellar Ataxia type 3

Interventions

True stimulation:Repetitive transcranial magnetic stimulation (rTMS)

placebo:Sham stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of the Spinocerebellar Ataxia scales, such as SARA, ICARS; 2. Aged 18 to 75 years; 3. Able to communicate with interviewers and complete scales independently; 4. Endorse the informed consent

Exclusion criteria

Exclusion criteria: 1. Other hereditary disease; 2. Other severe central nervous system disease; 3. History of brain surgery; 4. Depression, Anxiety and other psychogenic disease; 5. With metal equipment or prosthesis (pacemaker, insulin pump) in body, claustrophobia, or other magnetic resonance examination contraindications.

Design outcomes

Primary

Measure	Time frame
CCAS;SARA;ICARS;25-ft walk;Rest-stating MRI;Diffusion tensor imaging;T1 grey structure imaging;SWI;MRI spectroscopy Imaging;	—

Secondary

Measure	Time frame
HAMD;CCFS;Digital Span;MoCA;Bio-chemical indicators;	—

Countries

China

Contacts

Public ContactChen Liu

The First Affiliated Hospital of Army Medical University

cqliuchen@foxmail.com+86 13108968808

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 11, 2026