colorectal cancer
Conditions
Interventions
Control Group (A Group):Systemic intra-venous chemotherapy
Experimental group (B Group):Regional arterial perfusion chemotherapy
Sponsors
The Third Affiliated Hospital affiliated to Sun Yat-Sen University
Eligibility
Sex/Gender
Male
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 20 and = 70, ECOG physical status score.
Exclusion criteria
Exclusion criteria: 1. Middle and low rectal cancer (distance from anus <= 12cm); 2. Familial adenomatous polyposis, Lynch syndrome and other hereditary colorectal cancers; 3. Preoperative imaging indicated distant organ metastasis, such as liver metastasis, lung metastasis, etc. 4. Patients with tumor complicated with acute ileus, perforation or bleeding, or requiring emergency surgery; 5. Patients with other malignant diseases or with other malignant diseases within 5 years, or with other diseases requiring simultaneous surgery; 6. A history of continuous systemic corticosteroid or immunosuppressive drug therapy within 1 month; 7. Expected survival less than 6 months; 8. Imaging examination or interventional catheter contrast allergy; 9. Severe heart, brain, liver, lung, kidney, hematopoietic system and other important organ diseases or functional insufficiency, unable to tolerate chemotherapy, intervention or surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| downstaging rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| disease control rate;pathologic complete response;R0 resection rates;complication;1 and 3-year overall survival;1 and 3-year disease free survival rate;1 and 3-year recurrence pattern; | — |
Countries
China
Contacts
Public ContactWei Bo
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed