Hepatocellular Carcinoma
Conditions
Interventions
Group B:Stereotactic Body Radiotherapy
Sponsors
The First Affiliated Hospital of Medical College of Zhejiang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients confirmed by pathology or meeting the clinical diagnostic criteria of hepatocellular carcinoma should be consulted by two specialists in the radiotherapy department and two specialists in the RFA department in the same center. RFA or SBRT is acceptable. 2. Patients with small hepatocellular carcinoma whose maximum diameter of tumor is less than or equal to 2cm: they are willing to choose non-surgical treatment for early hepatocellular carcinoma; local recurrence or intrahepatic metastasis but no extrahepatic metastasis. 3. Patients with tumor number less than or equal to 3. 4. Patients with ECoG score 0-2. 5. Child Pugh grade A-B, liver and kidney function in the normal range (ALT or ASL within 2 times of the normal value; Cr or bun within 2 times of the normal value), WBC > 2 x 10^9 / L, Hb > 90g / L, PLT > 30 x 10^9 / L. 6. Patients with an estimated survival time > 6 months. 7. Patients without previous upper abdominal radiotherapy. 8. Patients aged 18-80 years. 9. Patients with informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with any uncontrollable active infection, including but not limited to active tuberculosis subjects. 2. Patients with malignant tumor of other organs at the same time. 3. Subjects who participated in other clinical trials or used other research drugs or equipment within 4 weeks of the first treatment. 4. The patients with severe heart, lung and kidney diseases can not tolerate SBRT or RFA. 5. Pregnant or lactating women. 6. Patients with severe nervous system diseases can not clearly explain the treatment response. 7. Patients with HIV antibody, Treponema pallidum antibody or HCV-RNA positive. 8. Patients with previous or current hepatic encephalopathy. 9. Patients with clinically significant ascites are defined as ascites with positive signs of ascites on physical examination or controlled by intervention (e.g., puncture or drug therapy, etc.) (only those with ascites on imaging without intervention can be included). 10. Subjects with unstable or active ulcer, gastrointestinal bleeding, or intolerance to proton pump inhibitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local contral; | — |
Countries
China
Contacts
Public ContactLingbo Liang
The First Affiliated Hospital of Medical College of Zhejiang University
Outcome results
None listed