Major depressive disorder
Conditions
Interventions
Experimental group:antidepressants
Experimental group:Modified electroconvulsive therapy
Control group:Modified electroconvulsive therapy
Sponsors
Tongji Hospital of Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18-60 years, able to cooperate with rTMS and MECT treatment; 2) Obtain the written informed consent of the subjects and family members/legal guardians; 3) Meet the diagnostic criteria for severe depressive episodes in the International Classification of Diseases 10 (ICD-10); 4) Subjects HAMD-17 score >= 24 points; 5) Maintain a stable dose of antidepressants during the rTMS treatment period. The drugs are limited to SSRI or SNRI antidepressants. The equivalent dose of fluoxetine is 20-40 mg/d (the equivalent of antidepressants is converted to fluoxetine 20- 40mg/d, citalopram 20-40mg/d, escitalopram 9-18mg/d, paroxetine 17-34mg/d, sertraline 49.3-98.6mg/d, venlafaxine 74.7-149.4mg /d).
Exclusion criteria
Exclusion criteria: 1) There are contraindications to rTMS, MECT or MRI: 2) Patients with a history of alcohol and drug dependence and acute poisoning; a history of illegal drug abuse; patients with psychotic disorders, bipolar disorder, and obsessive-compulsive disorder; 3) There are metal foreign bodies in the skull, those with pacemakers, those with cochlear implants, and intracranial hypertension; 4) Mental retardation and nervous system diseases, major physical diseases; 5) History of brain trauma, MRI examination showed abnormal brain structure; 6) History of alcohol or drug abuse and dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| CGI;cognitive function;fMRI;ERP; | — |
Countries
China
Contacts
Public ContactLu Zheng
Tongji Hospital of Tongji University
Outcome results
None listed