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A study of perioperative changes of proBDNF in thoracoscopic partial lung resection

A study of perioperative changes of proBDNF in thoracoscopic partial lung resection

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000039387
Enrollment
Unknown
Registered
2020-10-25
Start date
2020-10-23
Completion date
Unknown
Last updated
2024-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thoracoscopic partial lung resection

Interventions

case series:no intervention

Sponsors

Department of Anesthesia, the Second Xiangya Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Elective thoracoscopic partial lung resection in the second Xiangya Hospital requiring general anesthesia; 2. Aged 18 to 75 years; 3. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing nerve block during perioperative period; 2. Patients with abnormal white blood cells in preoperative blood routine examination tested in the ward; 3. Patients undergoing reoperation for lung cancer; 4. Patients with autoimmune diseases; 5. Patients with severe abnormal liver and kidney functions; 6. Patients with a recent history of non-steroidal anti-inflammatory drugs or steroids; 7. Patients with a history of drug or narcotics dependence; 8. Patients with a history of mental disease.

Design outcomes

Primary

MeasureTime frame
percentage of white blood cell subsets;expression of proBDNF;concentration of BDNF;

Secondary

MeasureTime frame
expression of IL-1ß;expression of IL-6;expression of IL-8;expression of IL-10;expression of IL-17;expression of TNF-a;proliferation of white blood cell subsets;apoptosis of white blood cell subsets;ROS content;blood pressure;heart rate;procalcitonin;erythrocyte seedimentation rate;C-reactive protein;adrenocorticotropic hormon;cortisol;adrenalin;noradrenaline;liver function;kidney function;blood glucose;lactate;myocardial enzyme;NT-proBNP;D - dimer;endotoxin quantification;pain score;analgesic usage;length of surgery;pathological examination results;complications;ventilation time;tracheal extubation time;length of stay;expression of p75NTR;ICU length of stay;

Countries

China

Contacts

Public ContactRuping Dai

Department of Anesthesia, the Second Xiangya Hospital of Central South University

xyeyyrupingdai@csu.edu.cn+86 18974924753

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026