Exosomes derived from Neural stem cell Induces Osteogenesis and angiogenesis following traumatic brain injury

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000039377

Enrollment

Unknown

Registered

2020-10-25

Start date

2020-11-01

Completion date

Unknown

Last updated

2021-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone defect

Interventions

normal patient group:Nil

patient with limb fracture only:Nil

patient with TBI only:Nil

patient with limb fracture following TBI:Nil

Eligibility

Sex/Gender

All

Age

30 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-60 years, regardless of gender; 2. Patients with brain injury lasting for 6-10 days; 3. The fracture sites included foot, ankle, tibiofibula, femur, patella, hip, radius and ulna, hand, humerus, scapula and clavicle; 4. Patients who meet the criteria of fracture diagnosis; or patients who meet the criteria of moderate / severe traumatic brain injury (according to different groups): Fracture criteria: interruption of cortical continuity; Criteria of moderate / severe traumatic brain injury: history of traumatic brain injury; duration of injury more than 24h; Glasgow coma score less than or equal to 12 points; time of unconsciousness more than 30min; 5. Patients who are willing to participate in this trial and cooperate with data collection.

Exclusion criteria

Exclusion criteria: 1. Patients with other non limb fractures; 2. Patients with previous history of brain injury and fracture within 3 years; 3. Patients with pathological fracture or severe osteoporosis or osteogenesis imperfecta; 4. Patients with serious diseases of liver and kidney; 5. Patients with severe cardiovascular and hematological diseases 6. Diabetic patients; 7. Patients with autoimmune diseases; 8. Tumor patients and patients receiving radiotherapy and chemotherapy; 9. Patients with a history of mental illness, inability to communicate and answer questions, such as dementia, etc.; 10. Those patients whose blood and urine HCG tests show pregnancy.

Design outcomes

Primary

Measure	Time frame
microRNA high throughput sequencing;	—

Secondary

Measure	Time frame
expression of protein;	—

Countries

China

Contacts

Public ContactLi Xiaolin

Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University

lixiaolin@sjtu.edu.cn+86 18930177668

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026