Effect of ACEI/ARB in older patients undergoing noncardiac surgery
Conditions
Interventions
Group ACEI/ARB continued:ACEI / ARB taken routinely in the morning of operation
Group ACEI/ARB withheld:ACEI / ARB withheld in the morning of operation
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 60-80 years; 2. ASA II-III subjects who took ACEI or ARB drugs to treat hypertension for more than two weeks; 3. Patients scheduled for noncardiac surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Pregnant objects; 2. ACEI / ARB is used only at night, intermittently, or both; 3. Patients with uncontrollable hypertension (systolic blood pressure >= 180 mmHg or diastolic blood pressure >= 110 mmHg); 4. Patients with mean basal arterial pressure = B, creatinine >= 200 µ mol / L); 8. Patients who refused to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| perioperative hypotension events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of perioperative hypotension;Use of intravenous fluids and vasopressors;Postoperative hypotension events occurring in the surgical wards within 3 days after surgery;Perioperative neurocognitive disorders;Major adverse cardiocerebral events;Mortality within 30 days after surgery; | — |
Countries
China
Contacts
Public ContactFuhai Ji
The First Affiliated Hospital of Suzhou University
Outcome results
None listed