Efficacy and safety of postoperative intravenous tranexamic acid in total knee arthroplasty: a prospective randomized controlled study

Efficacy and safety of tranexamic acid in Orthopaedic surgery

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000039368

Enrollment

Unknown

Registered

2020-10-24

Start date

2020-10-26

Completion date

Unknown

Last updated

2021-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

group A:Tranexamic acid

group B:Tranexamic acid was applied a single time after surgery

group C:Nil

Eligibility

Sex/Gender

All

Age

55 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients without previous history of venous thrombosis; 2. Patients with knee osteoarthritis diagnosis and total knee arthroplasty 3. Patients with complete clinical data; 4. Patients aged 55-80 years.

Exclusion criteria

Exclusion criteria: 1. Patients with severe valgus deformity of knee joint; 2. Patients with abnormal fibrinolytic system; 3. Patients receiving anticoagulant therapy for a long time; 4. Patients with DVT before operation; 5. Patients with severe hepatic and renal insufficiency 6. Patients with significantly increased inflammatory indexes or infection.

Design outcomes

Primary

Measure	Time frame
Hb;Hct;DVT;	—

Countries

China

Contacts

Public ContactChenxi Xue

The Second Affiliated Hospital of Anhui Medical University

810987347@qq.com+86 13739279583

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026